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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GDNFGlial cell line-derived neurotrophic factor. (198 aa)    
Predicted Functional Partners:
GFRA1
GDNF family receptor alpha; Belongs to the GDNFR family.
    
 0.981
GFRA2
GDNF family receptor alpha; Belongs to the GDNFR family.
    
 0.933
RET
Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.
    
 0.924
GFRA3
GDNF family receptor alpha-3.
    
 0.866
GFRAL
LOW QUALITY PROTEIN: GDNF family receptor alpha-like.
    
 0.817
TH
Tyrosine 3-monooxygenase isoform X1.
      
 0.758
FGF8
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
      
 0.749
SMO
Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.
      
 0.712
EYA1
Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.
      
 0.700
GAB1
GRB2-associated-binding protein 1.
  
  
  0.630
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.