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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (303 aa)    
Predicted Functional Partners:
SCAP
Sterol regulatory element-binding protein cleavage-activating protein.
   
 0.859
HMGCR
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
 
 0.818
CHAF1B
Chromatin assembly factor 1 subunit B.
    
 
 0.717
AMFR
E3 ubiquitin-protein ligase AMFR.
    
 
 0.696
NPC1
NPC intracellular cholesterol transporter 1.
   
 0.634
NPC1L1
NPC1-like intracellular cholesterol transporter 1 isoform X1.
   
 0.634
ORC3
Origin recognition complex subunit 3 isoform X1.
    
   0.592
ORC5
Origin recognition complex subunit 5.
    
   0.592
HMGCS1
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
   
  
 0.576
PERP
P53 apoptosis effector related to PMP-22.
   
  
 0.564
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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