PAXIP1 protein (Vulpes vulpes) - STRING interaction network

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Score

PAXIP1

PAX-interacting protein 1. (1090 aa)

Predicted Functional Partners:

RIF1

0.933

TP53BP1

0.903

PAGR1

0.877

ATM

0.871

ASH2L

0.848

SMC6

0.842

NBN

0.837

SLF1

0.836

KDM6A

0.807

NCOA6

0.803

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASH2L	KDM6A	ENSVVUP00000027466	ENSVVUP00000016178	set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X2.	Lysine-specific demethylase 6A isoform X1.	0.936
ASH2L	NCOA6	ENSVVUP00000027466	ENSVVUP00000005520	set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X2.	Nuclear receptor coactivator 6 isoform X1.	0.965
ASH2L	PAGR1	ENSVVUP00000027466	ENSVVUP00000036389	set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X2.	PAXIP1-associated glutamate-rich protein 1.	0.797
ASH2L	PAXIP1	ENSVVUP00000027466	ENSVVUP00000003551	set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X2.	PAX-interacting protein 1.	0.848
ATM	NBN	ENSVVUP00000020826	ENSVVUP00000002620	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.998
ATM	PAXIP1	ENSVVUP00000020826	ENSVVUP00000003551	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	PAX-interacting protein 1.	0.871
ATM	RIF1	ENSVVUP00000020826	ENSVVUP00000016759	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Telomere-associated protein RIF1 isoform X1.	0.821
ATM	SLF1	ENSVVUP00000020826	ENSVVUP00000030264	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SMC5-SMC6 complex localization factor protein 1.	0.878
ATM	TP53BP1	ENSVVUP00000020826	ENSVVUP00000013305	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	TP53-binding protein 1 isoform X1.	0.959
KDM6A	ASH2L	ENSVVUP00000016178	ENSVVUP00000027466	Lysine-specific demethylase 6A isoform X1.	set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X2.	0.936
KDM6A	NCOA6	ENSVVUP00000016178	ENSVVUP00000005520	Lysine-specific demethylase 6A isoform X1.	Nuclear receptor coactivator 6 isoform X1.	0.865
KDM6A	PAGR1	ENSVVUP00000016178	ENSVVUP00000036389	Lysine-specific demethylase 6A isoform X1.	PAXIP1-associated glutamate-rich protein 1.	0.813
KDM6A	PAXIP1	ENSVVUP00000016178	ENSVVUP00000003551	Lysine-specific demethylase 6A isoform X1.	PAX-interacting protein 1.	0.807
NBN	ATM	ENSVVUP00000002620	ENSVVUP00000020826	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.998
NBN	PAXIP1	ENSVVUP00000002620	ENSVVUP00000003551	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	PAX-interacting protein 1.	0.837
NBN	RIF1	ENSVVUP00000002620	ENSVVUP00000016759	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	Telomere-associated protein RIF1 isoform X1.	0.513
NBN	SLF1	ENSVVUP00000002620	ENSVVUP00000030264	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	SMC5-SMC6 complex localization factor protein 1.	0.909
NBN	TP53BP1	ENSVVUP00000002620	ENSVVUP00000013305	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	TP53-binding protein 1 isoform X1.	0.757
NCOA6	ASH2L	ENSVVUP00000005520	ENSVVUP00000027466	Nuclear receptor coactivator 6 isoform X1.	set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X2.	0.965
NCOA6	KDM6A	ENSVVUP00000005520	ENSVVUP00000016178	Nuclear receptor coactivator 6 isoform X1.	Lysine-specific demethylase 6A isoform X1.	0.865