Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
HUNKHormonally up-regulated neu tumor-associated kinase. (634 aa)    
Predicted Functional Partners:
APPL1
DCC-interacting protein 13-alpha.
    
  0.792
APPL2
DCC-interacting protein 13-beta isoform X2.
    
  0.792
CHAF1B
Chromatin assembly factor 1 subunit B.
   
  
 0.753
TRAPPC1
Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family.
    
   0.669
SCN8A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
      
 0.656
ZBTB21
LOW QUALITY PROTEIN: zinc finger and BTB domain-containing protein 21.
    
 0.641
RPTOR
Regulatory-associated protein of mTOR isoform X1.
    
 0.592
MIS18A
Protein Mis18-alpha.
   
  
 0.572
BRD2
Bromodomain-containing protein 2.
    
 
 0.568
FNIP2
Folliculin-interacting protein 2 isoform X1.
    
 
 0.546
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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