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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PDCD6-2Programmed cell death protein 6 isoform X2. (177 aa)    
Predicted Functional Partners:
PDCD6IP
Programmed cell death 6-interacting protein isoform X2.
    
 
 0.686
HEBP2
Heme binding protein 2.
    
 
 0.525
SEC31A
Protein transport protein Sec31A isoform X2.
    
 
 0.498
SEC31B
Protein transport protein Sec31B isoform X4.
    
 
 0.498
CAST
Calpastatin isoform X2.
   
 0.467
MARCHF8
E3 ubiquitin-protein ligase MARCH8 isoform X1.
      
 0.452
FECH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.
   
    0.404
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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