TP53INP1 protein (Vulpes vulpes) - STRING interaction network

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Score

TP53INP1

Tumor protein p53-inducible nuclear protein 1 isoform X1. (238 aa)

Predicted Functional Partners:

TP53

0.793

HIPK2

0.687

NUPR1

0.603

LURAP1

0.538

TP73

0.507

TP63

0.497

HIPK1

0.495

ZNF326

0.464

TTC39C

0.461

APBB3

0.461

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBB3	TP53INP1	ENSVVUP00000017424	ENSVVUP00000003972	Amyloid-beta A4 precursor protein-binding family B member 3 isoform X4.	Tumor protein p53-inducible nuclear protein 1 isoform X1.	0.461
HIPK1	TP53	ENSVVUP00000010272	ENSVVUP00000039187	Homeodomain-interacting protein kinase 1 isoform X1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.983
HIPK1	TP53INP1	ENSVVUP00000010272	ENSVVUP00000003972	Homeodomain-interacting protein kinase 1 isoform X1.	Tumor protein p53-inducible nuclear protein 1 isoform X1.	0.495
HIPK2	TP53	ENSVVUP00000003065	ENSVVUP00000039187	Homeodomain-interacting protein kinase 2 isoform X1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.991
HIPK2	TP53INP1	ENSVVUP00000003065	ENSVVUP00000003972	Homeodomain-interacting protein kinase 2 isoform X1.	Tumor protein p53-inducible nuclear protein 1 isoform X1.	0.687
HIPK2	TP73	ENSVVUP00000003065	ENSVVUP00000037960	Homeodomain-interacting protein kinase 2 isoform X1.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.417
LURAP1	TP53INP1	ENSVVUP00000009752	ENSVVUP00000003972	Leucine rich adaptor protein 1.	Tumor protein p53-inducible nuclear protein 1 isoform X1.	0.538
NUPR1	TP53	ENSVVUP00000036175	ENSVVUP00000039187	Nuclear protein 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.462
NUPR1	TP53INP1	ENSVVUP00000036175	ENSVVUP00000003972	Nuclear protein 1.	Tumor protein p53-inducible nuclear protein 1 isoform X1.	0.603
TP53	HIPK1	ENSVVUP00000039187	ENSVVUP00000010272	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Homeodomain-interacting protein kinase 1 isoform X1.	0.983
TP53	HIPK2	ENSVVUP00000039187	ENSVVUP00000003065	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Homeodomain-interacting protein kinase 2 isoform X1.	0.991
TP53	NUPR1	ENSVVUP00000039187	ENSVVUP00000036175	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Nuclear protein 1.	0.462
TP53	TP53INP1	ENSVVUP00000039187	ENSVVUP00000003972	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Tumor protein p53-inducible nuclear protein 1 isoform X1.	0.793
TP53	TP63	ENSVVUP00000039187	ENSVVUP00000018205	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.787
TP53	TP73	ENSVVUP00000039187	ENSVVUP00000037960	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.976
TP53INP1	APBB3	ENSVVUP00000003972	ENSVVUP00000017424	Tumor protein p53-inducible nuclear protein 1 isoform X1.	Amyloid-beta A4 precursor protein-binding family B member 3 isoform X4.	0.461
TP53INP1	HIPK1	ENSVVUP00000003972	ENSVVUP00000010272	Tumor protein p53-inducible nuclear protein 1 isoform X1.	Homeodomain-interacting protein kinase 1 isoform X1.	0.495
TP53INP1	HIPK2	ENSVVUP00000003972	ENSVVUP00000003065	Tumor protein p53-inducible nuclear protein 1 isoform X1.	Homeodomain-interacting protein kinase 2 isoform X1.	0.687
TP53INP1	LURAP1	ENSVVUP00000003972	ENSVVUP00000009752	Tumor protein p53-inducible nuclear protein 1 isoform X1.	Leucine rich adaptor protein 1.	0.538
TP53INP1	NUPR1	ENSVVUP00000003972	ENSVVUP00000036175	Tumor protein p53-inducible nuclear protein 1 isoform X1.	Nuclear protein 1.	0.603