XRCC6 protein (Vulpes vulpes) - STRING interaction network

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Score

XRCC6

LOW QUALITY PROTEIN: X-ray repair cross-complementing protein 6. (593 aa)

Predicted Functional Partners:

XRCC5

0.990

WRN

0.985

PRKDC

0.907

MRE11

0.902

DCLRE1C

0.863

RAD50

0.815

TP53BP1

0.806

LIG3

0.781

LIG1

0.780

ATM

0.771

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	DCLRE1C	ENSVVUP00000020826	ENSVVUP00000006905	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein artemis isoform X2.	0.658
ATM	MRE11	ENSVVUP00000020826	ENSVVUP00000015733	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.998
ATM	PRKDC	ENSVVUP00000020826	ENSVVUP00000022479	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA-dependent protein kinase catalytic subunit isoform X2; Belongs to the PI3/PI4-kinase family.	0.696
ATM	RAD50	ENSVVUP00000020826	ENSVVUP00000034039	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA repair protein RAD50 isoform X1.	0.996
ATM	TP53BP1	ENSVVUP00000020826	ENSVVUP00000013305	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	TP53-binding protein 1 isoform X1.	0.959
ATM	WRN	ENSVVUP00000020826	ENSVVUP00000027052	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Werner syndrome ATP-dependent helicase.	0.979
ATM	XRCC5	ENSVVUP00000020826	ENSVVUP00000012044	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.868
ATM	XRCC6	ENSVVUP00000020826	ENSVVUP00000004450	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	LOW QUALITY PROTEIN: X-ray repair cross-complementing protein 6.	0.771
DCLRE1C	ATM	ENSVVUP00000006905	ENSVVUP00000020826	Protein artemis isoform X2.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.658
DCLRE1C	LIG1	ENSVVUP00000006905	ENSVVUP00000032128	Protein artemis isoform X2.	DNA ligase.	0.446
DCLRE1C	LIG3	ENSVVUP00000006905	ENSVVUP00000027951	Protein artemis isoform X2.	DNA ligase.	0.540
DCLRE1C	MRE11	ENSVVUP00000006905	ENSVVUP00000015733	Protein artemis isoform X2.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.825
DCLRE1C	PRKDC	ENSVVUP00000006905	ENSVVUP00000022479	Protein artemis isoform X2.	DNA-dependent protein kinase catalytic subunit isoform X2; Belongs to the PI3/PI4-kinase family.	0.958
DCLRE1C	RAD50	ENSVVUP00000006905	ENSVVUP00000034039	Protein artemis isoform X2.	DNA repair protein RAD50 isoform X1.	0.635
DCLRE1C	TP53BP1	ENSVVUP00000006905	ENSVVUP00000013305	Protein artemis isoform X2.	TP53-binding protein 1 isoform X1.	0.679
DCLRE1C	XRCC5	ENSVVUP00000006905	ENSVVUP00000012044	Protein artemis isoform X2.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.980
DCLRE1C	XRCC6	ENSVVUP00000006905	ENSVVUP00000004450	Protein artemis isoform X2.	LOW QUALITY PROTEIN: X-ray repair cross-complementing protein 6.	0.863
LIG1	DCLRE1C	ENSVVUP00000032128	ENSVVUP00000006905	DNA ligase.	Protein artemis isoform X2.	0.446
LIG1	LIG3	ENSVVUP00000032128	ENSVVUP00000027951	DNA ligase.	DNA ligase.	0.576
LIG1	MRE11	ENSVVUP00000032128	ENSVVUP00000015733	DNA ligase.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.696