close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NPC1NPC intracellular cholesterol transporter 1. (1276 aa)    
Predicted Functional Partners:
NPC2
NPC intracellular cholesterol transporter 2 isoform X1.
   
 0.995
ENSVVUP00000030976
annotation not available
   
 0.954
OSBPL5
Oxysterol-binding protein; Belongs to the OSBP family.
   
 0.948
SREBF1
Sterol regulatory element-binding protein 1 isoform X3.
   
 0.770
SREBF2
LOW QUALITY PROTEIN: sterol regulatory element-binding protein 2.
   
 0.769
LOC112912876
Sterol regulatory element-binding protein 2-like.
   
 0.769
GP2
Pancreatic secretory granule membrane major glycoprotein GP2 isoform X1.
   
  
 0.705
MYCN
N-myc proto-oncogene protein.
   
 0.704
INSIG1
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.
   
 0.634
INSIG2
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.
   
 0.634
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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