STAM protein (Vulpes vulpes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

STAM

Signal transducing adapter molecule 1 isoform X1. (538 aa)

Predicted Functional Partners:

HGS

0.999

STAM2

0.980

STAMBP

0.979

ENSVVUP00000007596

0.979

JAK3

0.939

JAK2

0.932

JAK1

0.925

RPS27A

0.868

ENSVVUP00000014764

0.868

ITSN2

0.837

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSVVUP00000007596	ENSVVUP00000014764	ENSVVUP00000007596	ENSVVUP00000014764	annotation not available	annotation not available	0.763
ENSVVUP00000007596	RPS27A	ENSVVUP00000007596	ENSVVUP00000013492	annotation not available	ubiquitin-40S ribosomal protein S27a.	0.763
ENSVVUP00000007596	STAM	ENSVVUP00000007596	ENSVVUP00000005086	annotation not available	Signal transducing adapter molecule 1 isoform X1.	0.979
ENSVVUP00000007596	STAM2	ENSVVUP00000007596	ENSVVUP00000019419	annotation not available	Signal transducing adapter molecule 2 isoform X1.	0.925
ENSVVUP00000014764	ENSVVUP00000007596	ENSVVUP00000014764	ENSVVUP00000007596	annotation not available	annotation not available	0.763
ENSVVUP00000014764	HGS	ENSVVUP00000014764	ENSVVUP00000027209	annotation not available	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.878
ENSVVUP00000014764	ITSN2	ENSVVUP00000014764	ENSVVUP00000017571	annotation not available	Intersectin-2 isoform X4.	0.537
ENSVVUP00000014764	JAK1	ENSVVUP00000014764	ENSVVUP00000018991	annotation not available	Tyrosine-protein kinase.	0.452
ENSVVUP00000014764	JAK2	ENSVVUP00000014764	ENSVVUP00000009883	annotation not available	Tyrosine-protein kinase.	0.452
ENSVVUP00000014764	STAM	ENSVVUP00000014764	ENSVVUP00000005086	annotation not available	Signal transducing adapter molecule 1 isoform X1.	0.868
ENSVVUP00000014764	STAM2	ENSVVUP00000014764	ENSVVUP00000019419	annotation not available	Signal transducing adapter molecule 2 isoform X1.	0.830
ENSVVUP00000014764	STAMBP	ENSVVUP00000014764	ENSVVUP00000006099	annotation not available	STAM-binding protein.	0.763
HGS	ENSVVUP00000014764	ENSVVUP00000027209	ENSVVUP00000014764	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	annotation not available	0.878
HGS	ITSN2	ENSVVUP00000027209	ENSVVUP00000017571	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Intersectin-2 isoform X4.	0.841
HGS	RPS27A	ENSVVUP00000027209	ENSVVUP00000013492	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	ubiquitin-40S ribosomal protein S27a.	0.878
HGS	STAM	ENSVVUP00000027209	ENSVVUP00000005086	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Signal transducing adapter molecule 1 isoform X1.	0.999
HGS	STAM2	ENSVVUP00000027209	ENSVVUP00000019419	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	Signal transducing adapter molecule 2 isoform X1.	0.999
ITSN2	ENSVVUP00000014764	ENSVVUP00000017571	ENSVVUP00000014764	Intersectin-2 isoform X4.	annotation not available	0.537
ITSN2	HGS	ENSVVUP00000017571	ENSVVUP00000027209	Intersectin-2 isoform X4.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.841
ITSN2	JAK1	ENSVVUP00000017571	ENSVVUP00000018991	Intersectin-2 isoform X4.	Tyrosine-protein kinase.	0.493