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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TJP2Tight junction protein ZO-2 isoform X4; Belongs to the MAGUK family. (1195 aa)    
Predicted Functional Partners:
TJP1
Tight junction protein ZO-1 isoform X1; Belongs to the MAGUK family.
    
0.972
F11R
Junctional adhesion molecule A.
   
 0.964
YAP1
Transcriptional coactivator YAP1.
   
 0.942
WWTR1
WW domain-containing transcription regulator protein 1.
   
 0.933
RAPGEF2
Rap guanine nucleotide exchange factor 2 isoform X1.
    
 0.921
OCLN
Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family.
   
 
 0.844
CASP3
Caspase-3 isoform X1; Belongs to the peptidase C14A family.
    
 0.781
GJA1
Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
   
 0.738
ENSVVUP00000019282
annotation not available
   
 0.699
AFDN
Afadin isoform X8.
   
 
 0.668
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.