ASIP protein (Vulpes vulpes) - STRING interaction network

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ASIP

Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). (79 aa)

Predicted Functional Partners:

MC1R

0.974

TYR

0.829

LOC112934480

0.816

AHCY

0.759

TYRP1

0.663

ATRN

0.663

EDN3

0.605

STX17

0.604

MITF

0.603

DCT

0.576

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHCY	ASIP	ENSVVUP00000005723	ENSVVUP00000005760	Adenosylhomocysteinase.	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	0.759
ASIP	AHCY	ENSVVUP00000005760	ENSVVUP00000005723	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Adenosylhomocysteinase.	0.759
ASIP	ATRN	ENSVVUP00000005760	ENSVVUP00000034522	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Attractin.	0.663
ASIP	DCT	ENSVVUP00000005760	ENSVVUP00000008586	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	L-dopachrome tautomerase isoform X1.	0.576
ASIP	EDN3	ENSVVUP00000005760	ENSVVUP00000021992	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Endothelin-3 isoform X1.	0.605
ASIP	LOC112934480	ENSVVUP00000005760	ENSVVUP00000041664	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Beta-defensin 103-like.	0.816
ASIP	MC1R	ENSVVUP00000005760	ENSVVUP00000005692	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family.	0.974
ASIP	MITF	ENSVVUP00000005760	ENSVVUP00000018964	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Microphthalmia-associated transcription factor isoform X3.	0.603
ASIP	STX17	ENSVVUP00000005760	ENSVVUP00000026345	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Syntaxin-17; Belongs to the syntaxin family.	0.604
ASIP	TYR	ENSVVUP00000005760	ENSVVUP00000025620	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Tyrosinase.	0.829
ASIP	TYRP1	ENSVVUP00000005760	ENSVVUP00000028249	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	5,6-dihydroxyindole-2-carboxylic acid oxidase.	0.663
ATRN	ASIP	ENSVVUP00000034522	ENSVVUP00000005760	Attractin.	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	0.663
ATRN	LOC112934480	ENSVVUP00000034522	ENSVVUP00000041664	Attractin.	Beta-defensin 103-like.	0.622
ATRN	MC1R	ENSVVUP00000034522	ENSVVUP00000005692	Attractin.	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family.	0.421
DCT	ASIP	ENSVVUP00000008586	ENSVVUP00000005760	L-dopachrome tautomerase isoform X1.	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	0.576
DCT	EDN3	ENSVVUP00000008586	ENSVVUP00000021992	L-dopachrome tautomerase isoform X1.	Endothelin-3 isoform X1.	0.542
DCT	MC1R	ENSVVUP00000008586	ENSVVUP00000005692	L-dopachrome tautomerase isoform X1.	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family.	0.443
DCT	MITF	ENSVVUP00000008586	ENSVVUP00000018964	L-dopachrome tautomerase isoform X1.	Microphthalmia-associated transcription factor isoform X3.	0.546
DCT	TYR	ENSVVUP00000008586	ENSVVUP00000025620	L-dopachrome tautomerase isoform X1.	Tyrosinase.	0.639
DCT	TYRP1	ENSVVUP00000008586	ENSVVUP00000028249	L-dopachrome tautomerase isoform X1.	5,6-dihydroxyindole-2-carboxylic acid oxidase.	0.902

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