close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)    
Predicted Functional Partners:
PIK3R1
Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.
   
 0.999
LOC112914774
Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1.
   
 0.998
RRAS
Ras-related protein R-Ras.
   
 0.994
KRAS
GTPase KRas isoform X1.
   
 0.993
EGFR
Receptor protein-tyrosine kinase.
    
 0.992
PIK3R2
Phosphatidylinositol 3-kinase regulatory subunit beta.
   
 0.990
MRAS
Ras-related protein M-Ras.
   
 0.985
PIK3R5
Phosphoinositide 3-kinase regulatory subunit 5 isoform X1.
   
 0.983
NRAS
GTPase NRas.
   
 0.982
HRAS
GTPase HRas isoform X1.
   
 0.982
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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