ZMPSTE24 protein (Vulpes vulpes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ZMPSTE24

CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (473 aa)

Predicted Functional Partners:

ICMT

0.980

FNTB

0.932

RCE1

0.921

LMNB2

0.748

LMNB1

0.640

LMNA

0.609

GRPEL1

0.572

GRPEL2

0.572

CLPB

0.571

EMD

0.525

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLPB	GRPEL1	ENSVVUP00000034445	ENSVVUP00000000068	Caseinolytic peptidase B protein homolog isoform X1.	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.	0.889
CLPB	GRPEL2	ENSVVUP00000034445	ENSVVUP00000019504	Caseinolytic peptidase B protein homolog isoform X1.	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.	0.882
CLPB	ZMPSTE24	ENSVVUP00000034445	ENSVVUP00000006656	Caseinolytic peptidase B protein homolog isoform X1.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.571
EMD	LMNA	ENSVVUP00000041555	ENSVVUP00000007727	Emerin.	Lamin; Belongs to the intermediate filament family.	0.987
EMD	LMNB1	ENSVVUP00000041555	ENSVVUP00000042479	Emerin.	lamin-B1 isoform X1; Belongs to the intermediate filament family.	0.968
EMD	LMNB2	ENSVVUP00000041555	ENSVVUP00000003550	Emerin.	lamin-B2; Belongs to the intermediate filament family.	0.925
EMD	ZMPSTE24	ENSVVUP00000041555	ENSVVUP00000006656	Emerin.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.525
FNTB	ICMT	ENSVVUP00000040718	ENSVVUP00000036898	Protein farnesyltransferase subunit beta; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.	Protein-S-isoprenylcysteine O-methyltransferase.	0.604
FNTB	RCE1	ENSVVUP00000040718	ENSVVUP00000014454	Protein farnesyltransferase subunit beta; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.	CAAX prenyl protease 2 isoform X2.	0.856
FNTB	ZMPSTE24	ENSVVUP00000040718	ENSVVUP00000006656	Protein farnesyltransferase subunit beta; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.932
GRPEL1	CLPB	ENSVVUP00000000068	ENSVVUP00000034445	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.	Caseinolytic peptidase B protein homolog isoform X1.	0.889
GRPEL1	ZMPSTE24	ENSVVUP00000000068	ENSVVUP00000006656	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.572
GRPEL2	CLPB	ENSVVUP00000019504	ENSVVUP00000034445	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.	Caseinolytic peptidase B protein homolog isoform X1.	0.882
GRPEL2	ZMPSTE24	ENSVVUP00000019504	ENSVVUP00000006656	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.572
ICMT	FNTB	ENSVVUP00000036898	ENSVVUP00000040718	Protein-S-isoprenylcysteine O-methyltransferase.	Protein farnesyltransferase subunit beta; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.	0.604
ICMT	LMNB2	ENSVVUP00000036898	ENSVVUP00000003550	Protein-S-isoprenylcysteine O-methyltransferase.	lamin-B2; Belongs to the intermediate filament family.	0.518
ICMT	RCE1	ENSVVUP00000036898	ENSVVUP00000014454	Protein-S-isoprenylcysteine O-methyltransferase.	CAAX prenyl protease 2 isoform X2.	0.822
ICMT	ZMPSTE24	ENSVVUP00000036898	ENSVVUP00000006656	Protein-S-isoprenylcysteine O-methyltransferase.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.980
LMNA	EMD	ENSVVUP00000007727	ENSVVUP00000041555	Lamin; Belongs to the intermediate filament family.	Emerin.	0.987
LMNA	LMNB1	ENSVVUP00000007727	ENSVVUP00000042479	Lamin; Belongs to the intermediate filament family.	lamin-B1 isoform X1; Belongs to the intermediate filament family.	0.995