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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DCAF7DDB1- and CUL4-associated factor 7. (342 aa)    
Predicted Functional Partners:
DYRK1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1.
   
 
 0.929
DDB1
DNA damage-binding protein 1.
    
 0.925
HIPK2
Homeodomain-interacting protein kinase 2 isoform X1.
   
 
 0.894
DYRK1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2.
   
 
 0.888
DTL
Denticleless protein homolog isoform X1.
     
 0.795
ERCC8
DNA excision repair protein ERCC-8 isoform X2.
     
 0.778
CUL4A
cullin-4A; Belongs to the cullin family.
    
 0.763
DCAF11
DDB1- and CUL4-associated factor 11; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat LEC14B family.
    
 0.760
CUL4B
cullin-4B isoform X2; Belongs to the cullin family.
    
 0.759
DCAF10
DDB1- and CUL4-associated factor 10.
   
 
 0.734
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.