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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SEMA4Asemaphorin-4A; Belongs to the semaphorin family. (585 aa)    
Predicted Functional Partners:
PLXNB2
plexin-B2.
    
0.969
PLXND1
plexin-D1.
    
 0.963
ENSVVUP00000007731
annotation not available
 
      0.866
PLXNA1
plexin-A1.
    
0.639
ENSVVUP00000004522
annotation not available
    
 0.619
MET
Hepatocyte growth factor receptor isoform X1.
    
 0.609
MST1R
Macrophage-stimulating protein receptor isoform X3.
    
 0.609
PLXNB3
plexin-B3 isoform X8.
    
0.554
PLXNA4
plexin-A4.
    
0.489
PLXNC1
plexin-C1.
    
0.483
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.