close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RNF216E3 ubiquitin-protein ligase RNF216 isoform X1. (927 aa)    
Predicted Functional Partners:
OTUD4
OTU domain-containing protein 4.
    
 0.793
SACS
Sacsin.
    
 0.787
RNF14
RBR-type E3 ubiquitin transferase.
     
 0.747
ZNF280D
Zinc finger protein 280D isoform X1.
    
 
 0.733
KIF26B
Kinesin-like protein KIF26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
      
 0.728
RPS27A
ubiquitin-40S ribosomal protein S27a.
   
 0.719
ENSVVUP00000014764
annotation not available
   
 0.719
UBA52
ubiquitin-60S ribosomal protein L40.
    
  0.710
ENSVVUP00000040094
annotation not available
    
  0.710
LOC112910913
Ubiquitin-like.
   
 0.664
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
Server load: low (28%) [HD]