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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (771 aa)    
Predicted Functional Partners:
CTNNB1
Catenin beta-1 isoform X1.
    
 0.986
PECAM1
Platelet endothelial cell adhesion molecule isoform X1.
   
 0.979
CTNND1
Catenin delta-1 isoform X1.
    
 0.961
JUP
Junction plakoglobin.
    
 0.855
PARD3
Partitioning defective 3 homolog.
    
 
 0.844
CLDN5
Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
   
  
 0.829
CTNNA2
Catenin alpha-2 isoform X1.
    
 0.822
ENSVVUP00000004152
annotation not available
    
 0.822
CTNNA1
Catenin alpha-1.
    
 0.822
VWF
Von Willebrand factor.
   
 
 0.768
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.