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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EPN1Epsin-1 isoform X1. (569 aa)    
Predicted Functional Partners:
EPS15L1
Epidermal growth factor receptor substrate 15-like 1 isoform X2.
   
 0.994
EPS15
Epidermal growth factor receptor substrate 15 isoform X1.
   
 0.983
EGFR
Receptor protein-tyrosine kinase.
    
 0.975
CBL
E3 ubiquitin-protein ligase CBL.
   
 
 0.931
EPN2
Epsin-2 isoform X2.
  
  
 
0.930
GRB2
Growth factor receptor-bound protein 2.
   
 
 0.925
CLTC
Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.
   
 0.918
ITSN2
Intersectin-2 isoform X4.
    
 0.909
HIP1R
Huntingtin-interacting protein 1-related protein.
    
 
 0.828
ENSVVUP00000031532
annotation not available
    
 0.814
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.