Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PPP6R1Serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X2. (938 aa)    
Predicted Functional Partners:
PPP6C
Serine/threonine-protein phosphatase.
   
 0.991
ANKRD28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1.
   
 0.894
ANKRD52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C isoform X1.
    
 0.880
ANKRD44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1.
   
 0.833
ANKRD66
Ankyrin repeat domain-containing protein 66.
   
 0.833
USP10
Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.
   
   0.814
MED14
Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    
   0.744
PPP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1.
   
 
 0.736
PPP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1.
   
 
 0.729
NFKBIE
NF-kappa-B inhibitor epsilon.
    
 0.718
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.