close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ALKTyrosine-protein kinase receptor. (1625 aa)    
Predicted Functional Partners:
EML4
Echinoderm microtubule-associated protein-like 4 isoform X1.
   
 0.985
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
    
 0.980
PTN
Pleiotrophin.
    
 0.979
KRAS
GTPase KRas isoform X1.
   
 0.970
MDK
Midkine.
    
 0.965
PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
    
 0.962
PIK3R1
Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.
    
 0.961
JAK3
Tyrosine-protein kinase.
    
0.956
PIK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.
    
 0.956
NRAS
GTPase NRas.
   
 0.955
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.