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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (381 aa)    
Predicted Functional Partners:
PRKACA
cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily.
 
 
 0.999
PRKACB
cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily.
 
 
 0.996
AKAP10
A-kinase anchor protein 10, mitochondrial isoform X1.
   
 0.984
PRKX
cAMP-dependent protein kinase catalytic subunit PRKX; Belongs to the protein kinase superfamily.
 
 
 0.962
PRKAR2B
cAMP-dependent protein kinase type II-beta regulatory subunit.
  
  
0.940
PRKAR2A
cAMP-dependent protein kinase type II-alpha regulatory subunit.
  
  
0.940
PRKAR1B
cAMP-dependent protein kinase type I-beta regulatory subunit.
  
  
 
0.921
LIPE
Hormone-sensitive lipase.
     
 0.904
PRKCH
Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...]
 
   
 0.759
THAP7
THAP domain-containing protein 7.
   
 0.667
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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