Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TMEM33Transmembrane protein 33. (246 aa)    
Predicted Functional Partners:
TMED1
Transmembrane emp24 domain-containing protein 1 isoform X3.
   
  
 0.755
BEND4
BEN domain-containing protein 4.
      
 0.678
HSD17B12
Very-long-chain 3-oxoacyl-CoA reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.625
CFAP299
Uncharacterized protein C4orf22 homolog isoform X2.
      
 0.595
RTN1
Reticulon.
   
 
 0.577
RNF185
E3 ubiquitin-protein ligase RNF185.
    
 
 0.571
NUP133
Nuclear pore complex protein Nup133.
    
 
 0.568
SLC30A9
Zinc transporter 9.
   
  
 0.567
AGO2
Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]
    
   0.567
SEL1L
Protein sel-1 homolog 1.
   
  
 0.557
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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