close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IGFBP5Insulin-like growth factor-binding protein 5. (271 aa)    
Predicted Functional Partners:
IGF1
Insulin-like growth factor I isoform X1.
   
 0.991
IGFALS
Insulin-like growth factor-binding protein complex acid labile subunit.
   
 0.896
IGF2
Insulin-like growth factor II isoform X2.
   
 0.881
PAPPA
Pappalysin-1.
    
 0.846
PAPPA2
Pappalysin-2.
    
 0.723
FAM20C
Extracellular serine/threonine protein kinase FAM20C.
    
 0.573
IGF1R
Tyrosine-protein kinase receptor.
   
 
 0.536
INS
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
      
 0.518
IGFBP7
Insulin-like growth factor-binding protein 7.
      
 0.499
LUM
Lumican.
   
 0.488
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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