close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RFXANKDNA-binding protein RFXANK. (260 aa)    
Predicted Functional Partners:
RFX5
DNA-binding protein RFX5 isoform X1.
   
 0.996
RFXAP
Regulatory factor X-associated protein.
    
 0.990
CIITA
MHC class II transactivator.
   
 0.967
RFX7
DNA-binding protein RFX7 isoform X1.
    
 
 0.874
CAMKMT
Calmodulin-lysine N-methyltransferase isoform X2.
    
 
 0.694
HDAC4
Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
   
 0.666
CIB3
Calcium and integrin-binding family member 3 isoform X1.
    
 0.641
NR2C2AP
Nuclear receptor 2C2-associated protein.
   
 0.637
KANK2
KN motif and ankyrin repeat domain-containing protein 2 isoform X1.
  
   
 0.632
TXNDC12
Thioredoxin domain-containing protein 12.
      
 0.606
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
Server load: low (30%) [HD]