NLRP2 protein (Vulpes vulpes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NLRP2

NACHT, LRR and PYD domains-containing protein 2. (191 aa)

Predicted Functional Partners:

RIPK2

0.473

LOC112925945

0.470

LOC112915024

0.467

PYCARD

0.444

NCR1

0.442

NLRP6

0.441

TXNIP

0.410

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC112915024	NLRP2	ENSVVUP00000012314	ENSVVUP00000010371	Ribonuclease pancreatic-like; Belongs to the pancreatic ribonuclease family.	NACHT, LRR and PYD domains-containing protein 2.	0.467
LOC112925945	NLRP2	ENSVVUP00000018896	ENSVVUP00000010371	Caspase-1-like; Belongs to the peptidase C14A family.	NACHT, LRR and PYD domains-containing protein 2.	0.470
LOC112925945	NLRP6	ENSVVUP00000018896	ENSVVUP00000023080	Caspase-1-like; Belongs to the peptidase C14A family.	NACHT, LRR and PYD domains-containing protein 6.	0.663
LOC112925945	PYCARD	ENSVVUP00000018896	ENSVVUP00000038970	Caspase-1-like; Belongs to the peptidase C14A family.	Apoptosis-associated speck-like protein containing a CARD isoform X1.	0.983
LOC112925945	TXNIP	ENSVVUP00000018896	ENSVVUP00000010200	Caspase-1-like; Belongs to the peptidase C14A family.	Thioredoxin-interacting protein.	0.607
NCR1	NLRP2	ENSVVUP00000010390	ENSVVUP00000010371	Natural cytotoxicity triggering receptor 1.	NACHT, LRR and PYD domains-containing protein 2.	0.442
NLRP2	LOC112915024	ENSVVUP00000010371	ENSVVUP00000012314	NACHT, LRR and PYD domains-containing protein 2.	Ribonuclease pancreatic-like; Belongs to the pancreatic ribonuclease family.	0.467
NLRP2	LOC112925945	ENSVVUP00000010371	ENSVVUP00000018896	NACHT, LRR and PYD domains-containing protein 2.	Caspase-1-like; Belongs to the peptidase C14A family.	0.470
NLRP2	NCR1	ENSVVUP00000010371	ENSVVUP00000010390	NACHT, LRR and PYD domains-containing protein 2.	Natural cytotoxicity triggering receptor 1.	0.442
NLRP2	NLRP6	ENSVVUP00000010371	ENSVVUP00000023080	NACHT, LRR and PYD domains-containing protein 2.	NACHT, LRR and PYD domains-containing protein 6.	0.441
NLRP2	PYCARD	ENSVVUP00000010371	ENSVVUP00000038970	NACHT, LRR and PYD domains-containing protein 2.	Apoptosis-associated speck-like protein containing a CARD isoform X1.	0.444
NLRP2	RIPK2	ENSVVUP00000010371	ENSVVUP00000002520	NACHT, LRR and PYD domains-containing protein 2.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.473
NLRP2	TXNIP	ENSVVUP00000010371	ENSVVUP00000010200	NACHT, LRR and PYD domains-containing protein 2.	Thioredoxin-interacting protein.	0.410
NLRP6	LOC112925945	ENSVVUP00000023080	ENSVVUP00000018896	NACHT, LRR and PYD domains-containing protein 6.	Caspase-1-like; Belongs to the peptidase C14A family.	0.663
NLRP6	NLRP2	ENSVVUP00000023080	ENSVVUP00000010371	NACHT, LRR and PYD domains-containing protein 6.	NACHT, LRR and PYD domains-containing protein 2.	0.441
NLRP6	PYCARD	ENSVVUP00000023080	ENSVVUP00000038970	NACHT, LRR and PYD domains-containing protein 6.	Apoptosis-associated speck-like protein containing a CARD isoform X1.	0.958
PYCARD	LOC112925945	ENSVVUP00000038970	ENSVVUP00000018896	Apoptosis-associated speck-like protein containing a CARD isoform X1.	Caspase-1-like; Belongs to the peptidase C14A family.	0.983
PYCARD	NLRP2	ENSVVUP00000038970	ENSVVUP00000010371	Apoptosis-associated speck-like protein containing a CARD isoform X1.	NACHT, LRR and PYD domains-containing protein 2.	0.444
PYCARD	NLRP6	ENSVVUP00000038970	ENSVVUP00000023080	Apoptosis-associated speck-like protein containing a CARD isoform X1.	NACHT, LRR and PYD domains-containing protein 6.	0.958
PYCARD	TXNIP	ENSVVUP00000038970	ENSVVUP00000010200	Apoptosis-associated speck-like protein containing a CARD isoform X1.	Thioredoxin-interacting protein.	0.437