ATF3 protein (Vulpes vulpes) - STRING interaction network

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Score

ATF3

Cyclic AMP-dependent transcription factor ATF-3. (181 aa)

Predicted Functional Partners:

DDIT3

0.899

ATF4

0.835

JUNB

0.824

TP53

0.784

GAP43

0.716

TRPV1

0.697

TRIB3

0.685

XBP1

0.661

CHAC1

0.659

EGR1

0.652

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF3	ATF4	ENSVVUP00000010698	ENSVVUP00000019651	Cyclic AMP-dependent transcription factor ATF-3.	Cyclic AMP-dependent transcription factor ATF-4.	0.835
ATF3	CHAC1	ENSVVUP00000010698	ENSVVUP00000037318	Cyclic AMP-dependent transcription factor ATF-3.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.659
ATF3	DDIT3	ENSVVUP00000010698	ENSVVUP00000024483	Cyclic AMP-dependent transcription factor ATF-3.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.899
ATF3	EGR1	ENSVVUP00000010698	ENSVVUP00000024864	Cyclic AMP-dependent transcription factor ATF-3.	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.	0.652
ATF3	GAP43	ENSVVUP00000010698	ENSVVUP00000030417	Cyclic AMP-dependent transcription factor ATF-3.	Neuromodulin isoform X4.	0.716
ATF3	JUNB	ENSVVUP00000010698	ENSVVUP00000033334	Cyclic AMP-dependent transcription factor ATF-3.	Transcription factor jun-B.	0.824
ATF3	TP53	ENSVVUP00000010698	ENSVVUP00000039187	Cyclic AMP-dependent transcription factor ATF-3.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.784
ATF3	TRIB3	ENSVVUP00000010698	ENSVVUP00000011216	Cyclic AMP-dependent transcription factor ATF-3.	Tribbles homolog 3.	0.685
ATF3	TRPV1	ENSVVUP00000010698	ENSVVUP00000036048	Cyclic AMP-dependent transcription factor ATF-3.	Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family.	0.697
ATF3	XBP1	ENSVVUP00000010698	ENSVVUP00000035892	Cyclic AMP-dependent transcription factor ATF-3.	LOW QUALITY PROTEIN: X-box-binding protein 1.	0.661
ATF4	ATF3	ENSVVUP00000019651	ENSVVUP00000010698	Cyclic AMP-dependent transcription factor ATF-4.	Cyclic AMP-dependent transcription factor ATF-3.	0.835
ATF4	CHAC1	ENSVVUP00000019651	ENSVVUP00000037318	Cyclic AMP-dependent transcription factor ATF-4.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.733
ATF4	DDIT3	ENSVVUP00000019651	ENSVVUP00000024483	Cyclic AMP-dependent transcription factor ATF-4.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.990
ATF4	TRIB3	ENSVVUP00000019651	ENSVVUP00000011216	Cyclic AMP-dependent transcription factor ATF-4.	Tribbles homolog 3.	0.802
ATF4	XBP1	ENSVVUP00000019651	ENSVVUP00000035892	Cyclic AMP-dependent transcription factor ATF-4.	LOW QUALITY PROTEIN: X-box-binding protein 1.	0.805
CHAC1	ATF3	ENSVVUP00000037318	ENSVVUP00000010698	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Cyclic AMP-dependent transcription factor ATF-3.	0.659
CHAC1	ATF4	ENSVVUP00000037318	ENSVVUP00000019651	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Cyclic AMP-dependent transcription factor ATF-4.	0.733
CHAC1	TRIB3	ENSVVUP00000037318	ENSVVUP00000011216	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Tribbles homolog 3.	0.919
CHAC1	XBP1	ENSVVUP00000037318	ENSVVUP00000035892	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	LOW QUALITY PROTEIN: X-box-binding protein 1.	0.515
DDIT3	ATF3	ENSVVUP00000024483	ENSVVUP00000010698	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Cyclic AMP-dependent transcription factor ATF-3.	0.899