STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (137 aa)    
Predicted Functional Partners:
LOC112922479
C-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family.
   
 
 0.965
LOC112922564
C-X-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family.
   
 
 0.965
PPBP
Platelet basic protein-like.
  
 
0.960
IL1B
Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.
   
  
 0.941
NFKB1
Nuclear factor NF-kappa-B p105 subunit isoform X1.
   
 
 0.937
ACKR1
Atypical chemokine receptor 1.
     
 0.924
RELA
Transcription factor p65 isoform X2.
   
 
 0.903
CCR2
C-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family.
   
 
 0.845
CXCR4
C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family.
   
 
 0.845
ENSVVUP00000019941
annotation not available
   
 
0.844
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.