STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IGF1Insulin-like growth factor I isoform X1. (187 aa)    
Predicted Functional Partners:
IGF1R
Tyrosine-protein kinase receptor.
    
 0.999
INSR
Tyrosine-protein kinase receptor.
    
 0.996
IGFBP1
Insulin-like growth factor-binding protein 1.
   
 0.994
ENSVVUP00000041494
annotation not available
   
 0.992
IGFBP5
Insulin-like growth factor-binding protein 5.
   
 0.991
IGFBP6
Insulin-like growth factor-binding protein 6.
   
 0.986
IGFBP2
Insulin-like growth factor-binding protein 2.
   
 0.985
INS
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
     
 0.980
IGFBP4
Insulin-like growth factor-binding protein 4.
   
 0.971
EGF
Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
     
 0.971
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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