STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ASF1AAnti-silencing function 1A histone chaperone. (204 aa)    
Predicted Functional Partners:
HIRA
Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.
    
 0.996
UBN1
Ubinuclein 1.
    
 0.994
NASP
Nuclear autoantigenic sperm protein.
   
 
 0.992
CABIN1
Calcineurin binding protein 1.
    
 0.989
ENSUAMP00000003497
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 
 0.981
TLK2
Tousled like kinase 2.
    
 
 0.959
MCM2
DNA helicase; Belongs to the MCM family.
   
 
 0.948
CHAF1B
Chromatin assembly factor 1 subunit B.
   
 
 0.914
ENSUAMP00000006129
Histone domain-containing protein.
   
 
 0.899
ENSUAMP00000006323
Histone H3; Belongs to the histone H3 family.
   
 
 0.899
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.