STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSUAMP00000011833C2H2-type domain-containing protein. (81 aa)    
Predicted Functional Partners:
MYC
Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.
    
 0.939
MAX
MYC associated factor X.
   
 0.843
SP1
Sp1 transcription factor.
    
  0.840
HUWE1
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.
    
   0.634
CRBN
Cereblon.
    
 
 0.555
DPH5
Diphthamide biosynthesis 5.
      
 0.528
ENSUAMP00000032975
Uncharacterized protein.
      
 0.526
DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2.
   
  
 0.483
DNAJC24
DnaJ heat shock protein family (Hsp40) member C24.
   
 0.480
MXD3
MAX dimerization protein 3.
    
 0.476
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.