STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CRLF3Cytokine receptor like factor 3. (430 aa)    
Predicted Functional Partners:
EPOR
Erythropoietin receptor; Receptor for erythropoietin.
      
 0.716
ENSUAMP00000024983
Uncharacterized protein.
      
 0.635
ENSUAMP00000001609
Uncharacterized protein.
      
 0.633
TEFM
Transcription elongation factor, mitochondrial.
      
 0.629
PPP6R1
Protein phosphatase 6 regulatory subunit 1.
      
 0.629
EPO
Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.
      
 0.623
HYI
Hydroxypyruvate isomerase (putative).
      
 0.594
EVI2B
Ecotropic viral integration site 2B.
      
 0.571
ENSUAMP00000024150
Uncharacterized protein.
      
 0.571
LRCH3
Leucine rich repeats and calponin homology domain containing 3.
    
 
 0.550
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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