STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSUAMP00000018312Uncharacterized protein. (98 aa)    
Predicted Functional Partners:
CDK5
Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.
    
 0.992
MAPT
Microtubule-associated protein.
   
 0.924
ENSUAMP00000015862
Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family.
   
 
 0.879
ENSUAMP00000000589
Uncharacterized protein.
   
 
 0.718
ENSUAMP00000027802
Uncharacterized protein; Belongs to the peptidase C2 family.
   
 
 0.718
ENSUAMP00000028147
Uncharacterized protein.
   
 
 0.718
ENSUAMP00000028149
Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family.
   
 
 0.718
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
     
 0.714
CRYBA2
Crystallin beta A2; Belongs to the beta/gamma-crystallin family.
      
 0.595
MST1R
Macrophage stimulating 1 receptor.
   
  0.561
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.