STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPIRE2Spire type actin nucleation factor 2. (679 aa)    
Predicted Functional Partners:
ENSUAMP00000011554
FH2 domain-containing protein.
    
 0.850
GRAP2
GRB2 related adaptor protein 2.
   
 0.810
GRB2
Growth factor receptor bound protein 2.
   
 0.714
JMY
Junction mediating and regulatory protein, p53 cofactor.
   
 0.709
ENSUAMP00000004134
Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 0.678
ENSUAMP00000015119
Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 0.678
ENSUAMP00000025298
Dilute domain-containing protein.
   
 0.678
DEF8
Differentially expressed in FDCP 8 homolog.
      
 0.663
SYK
Spleen associated tyrosine kinase.
   
 0.625
ENSUAMP00000025844
Uncharacterized protein.
    
 0.616
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.