STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)    
Predicted Functional Partners:
MYD88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
   
0.999
ENSUAMP00000025678
Uncharacterized protein.
   
 0.999
TIRAP
TIR domain containing adaptor protein.
   
 0.995
TICAM1
TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines.
   
 0.992
ENSUAMP00000026449
Uncharacterized protein.
   
 0.989
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.988
TLR2
Toll like receptor 2; Belongs to the Toll-like receptor family.
   
0.987
IRAK4
Interleukin 1 receptor associated kinase 4.
   
 0.987
TRAF3
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.984
TLR6
Toll like receptor 6; Belongs to the Toll-like receptor family.
   
0.983
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.