node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSUAMP00000005136 | EPO | ENSUAMP00000005136 | ENSUAMP00000037087 | Uncharacterized protein. | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | 0.981 |
ENSUAMP00000005136 | EPOR | ENSUAMP00000005136 | ENSUAMP00000035609 | Uncharacterized protein. | Erythropoietin receptor; Receptor for erythropoietin. | 0.945 |
ENSUAMP00000005136 | IL6 | ENSUAMP00000005136 | ENSUAMP00000030975 | Uncharacterized protein. | Interleukin 6. | 0.589 |
ENSUAMP00000005136 | JAK2 | ENSUAMP00000005136 | ENSUAMP00000008171 | Uncharacterized protein. | Tyrosine-protein kinase. | 0.623 |
ENSUAMP00000005136 | LEP | ENSUAMP00000005136 | ENSUAMP00000022211 | Uncharacterized protein. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.956 |
EPO | ENSUAMP00000005136 | ENSUAMP00000037087 | ENSUAMP00000005136 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Uncharacterized protein. | 0.981 |
EPO | EPOR | ENSUAMP00000037087 | ENSUAMP00000035609 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Erythropoietin receptor; Receptor for erythropoietin. | 0.994 |
EPO | IL2 | ENSUAMP00000037087 | ENSUAMP00000029343 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | 0.920 |
EPO | IL5 | ENSUAMP00000037087 | ENSUAMP00000019606 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. | 0.480 |
EPO | IL6 | ENSUAMP00000037087 | ENSUAMP00000030975 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Interleukin 6. | 0.942 |
EPO | JAK1 | ENSUAMP00000037087 | ENSUAMP00000011495 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Tyrosine-protein kinase. | 0.931 |
EPO | JAK2 | ENSUAMP00000037087 | ENSUAMP00000008171 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Tyrosine-protein kinase. | 0.968 |
EPO | JAK3 | ENSUAMP00000037087 | ENSUAMP00000023448 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Tyrosine-protein kinase. | 0.931 |
EPO | LEP | ENSUAMP00000037087 | ENSUAMP00000022211 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.972 |
EPO | TYK2 | ENSUAMP00000037087 | ENSUAMP00000025889 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | Tyrosine-protein kinase. | 0.560 |
EPOR | ENSUAMP00000005136 | ENSUAMP00000035609 | ENSUAMP00000005136 | Erythropoietin receptor; Receptor for erythropoietin. | Uncharacterized protein. | 0.945 |
EPOR | EPO | ENSUAMP00000035609 | ENSUAMP00000037087 | Erythropoietin receptor; Receptor for erythropoietin. | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | 0.994 |
EPOR | IL2 | ENSUAMP00000035609 | ENSUAMP00000029343 | Erythropoietin receptor; Receptor for erythropoietin. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | 0.940 |
EPOR | IL5 | ENSUAMP00000035609 | ENSUAMP00000019606 | Erythropoietin receptor; Receptor for erythropoietin. | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. | 0.942 |
EPOR | IL6 | ENSUAMP00000035609 | ENSUAMP00000030975 | Erythropoietin receptor; Receptor for erythropoietin. | Interleukin 6. | 0.927 |