STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CHEK2Checkpoint kinase 2. (571 aa)    
Predicted Functional Partners:
CHEK1
Checkpoint kinase 1.
   
0.996
ATR
ATR serine/threonine kinase.
    
 0.994
ATM
ATM serine/threonine kinase.
    
 0.990
TP53
Tumor protein p53.
    
 0.984
CDC25B
Cell division cycle 25B.
   
 0.979
BRCA1
BRCA1 DNA repair associated.
   
 0.975
CDC7
Cell division cycle 7.
    
 
 0.969
MCM4
Minichromosome maintenance complex component 4.
   
 
 0.955
PIEZO2
Piezo type mechanosensitive ion channel component 2.
    
 0.949
PIEZO1
Piezo type mechanosensitive ion channel component 1.
    
 0.949
Your Current Organism:
Salvator merianae
NCBI taxonomy Id: 96440
Other names: Argentine black and white tegu, S. merianae, Tupinambis merianae, ZFMK 89199
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.