STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HCN3Hyperpolarization activated cyclic nucleotide gated potassium channel 3. (807 aa)    
Predicted Functional Partners:
HCN2
Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2.
  
 
0.941
HCN1
Hyperpolarization activated cyclic nucleotide gated potassium channel 1.
  
 
0.941
NALCN
Sodium leak channel, non-selective.
    
 
 0.688
DUS2
Dihydrouridine synthase 2.
      
 0.638
COPRS
Coordinator of PRMT5 and differentiation stimulator.
      
 0.605
PAXBP1
PAX3 and PAX7 binding protein 1.
      
 0.598
CACNA1E
Voltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents.
   
 
 0.554
COMTD1
Catechol-O-methyltransferase domain containing 1.
   
  
 0.553
MAP6D1
MAP6 domain containing 1.
   
  
 0.544
TMC4
Transmembrane channel-like protein.
      
 0.535
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.