STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DAPP1Dual adaptor of phosphotyrosine and 3-phosphoinositides 1. (280 aa)    
Predicted Functional Partners:
PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
     
 0.839
FANCM
FA complementation group M.
   
 0.731
USP8
Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family.
     
 0.712
OTUD4
OTU deubiquitinase 4.
      
 0.610
DDIT4L
DNA damage inducible transcript 4 like.
      
 0.608
PLCG1
Phosphoinositide phospholipase C.
     
0.588
VAV3
Vav guanine nucleotide exchange factor 3.
   
 
 0.579
GRAP2
GRB2 related adaptor protein 2.
     
 0.572
TOX2
TOX high mobility group box family member 2.
   
 
 0.561
KLHL25
Kelch like family member 25.
    
 
 0.548
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.