STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHHSonic hedgehog signaling molecule. (267 aa)    
Predicted Functional Partners:
PTCH1
Patched 1.
   
 0.970
PTCH2
Patched 2.
   
 0.949
HHIP
Hedgehog interacting protein.
    
 0.949
DISP1
Dispatched RND transporter family member 1.
   
 0.944
CDON
Cell adhesion associated, oncogene regulated.
    
 0.940
BOC
BOC cell adhesion associated, oncogene regulated.
    
 0.928
GPC3
Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.
    
 0.873
GAS1
GDNF domain-containing protein.
    
 0.872
SMO
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.839
LRP2
LDL receptor related protein 2.
     
 0.795
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.