Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (142 aa)    
Predicted Functional Partners:
SCAP
SREBF chaperone.
    
 0.855
HMGCR
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
 
 0.841
AMFR
Autocrine motility factor receptor.
    
 
 0.810
CHAF1B
Chromatin assembly factor 1 subunit B.
   
 
 0.706
ERLIN2
ER lipid raft associated 2.
    
 
 0.677
SREBF2
Sterol regulatory element binding transcription factor 2.
   
 0.643
VCP
Valosin containing protein; Belongs to the AAA ATPase family.
   
 
 0.640
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
    
 
 0.599
RNF139
Ring finger protein 139.
    
 
 0.592
SREBF1
Sterol regulatory element binding transcription factor 1.
   
 0.586
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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