INSIG1 protein (Ailuropoda melanoleuca) - STRING interaction network

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Score

INSIG1

Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (142 aa)

Predicted Functional Partners:

SCAP

0.832

HMGCR

0.785

AMFR

0.696

CHAF1B

0.667

SREBF2

0.647

NPC1

0.581

NPC1L1

0.581

HMGCS1

0.574

IDI1

0.554

PERP

0.550

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMFR	HMGCR	ENSAMEP00000017557	ENSAMEP00000000725	Autocrine motility factor receptor.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.674
AMFR	INSIG1	ENSAMEP00000017557	ENSAMEP00000001288	Autocrine motility factor receptor.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.	0.696
CHAF1B	INSIG1	ENSAMEP00000005889	ENSAMEP00000001288	Chromatin assembly factor 1 subunit B.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.	0.667
HMGCR	AMFR	ENSAMEP00000000725	ENSAMEP00000017557	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Autocrine motility factor receptor.	0.674
HMGCR	HMGCS1	ENSAMEP00000000725	ENSAMEP00000004117	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.999
HMGCR	IDI1	ENSAMEP00000000725	ENSAMEP00000002011	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Isopentenyl-diphosphate delta isomerase 1.	0.817
HMGCR	INSIG1	ENSAMEP00000000725	ENSAMEP00000001288	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.	0.785
HMGCR	NPC1	ENSAMEP00000000725	ENSAMEP00000014619	3-hydroxy-3-methylglutaryl coenzyme A reductase.	NPC intracellular cholesterol transporter 1.	0.472
HMGCR	NPC1L1	ENSAMEP00000000725	ENSAMEP00000018705	3-hydroxy-3-methylglutaryl coenzyme A reductase.	NPC1 like intracellular cholesterol transporter 1.	0.538
HMGCR	SCAP	ENSAMEP00000000725	ENSAMEP00000013673	3-hydroxy-3-methylglutaryl coenzyme A reductase.	SREBF chaperone.	0.408
HMGCR	SREBF2	ENSAMEP00000000725	ENSAMEP00000016386	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Sterol regulatory element binding transcription factor 2.	0.717
HMGCS1	HMGCR	ENSAMEP00000004117	ENSAMEP00000000725	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.999
HMGCS1	IDI1	ENSAMEP00000004117	ENSAMEP00000002011	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Isopentenyl-diphosphate delta isomerase 1.	0.938
HMGCS1	INSIG1	ENSAMEP00000004117	ENSAMEP00000001288	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.	0.574
HMGCS1	SCAP	ENSAMEP00000004117	ENSAMEP00000013673	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	SREBF chaperone.	0.439
HMGCS1	SREBF2	ENSAMEP00000004117	ENSAMEP00000016386	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Sterol regulatory element binding transcription factor 2.	0.598
IDI1	HMGCR	ENSAMEP00000002011	ENSAMEP00000000725	Isopentenyl-diphosphate delta isomerase 1.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.817
IDI1	HMGCS1	ENSAMEP00000002011	ENSAMEP00000004117	Isopentenyl-diphosphate delta isomerase 1.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.938
IDI1	INSIG1	ENSAMEP00000002011	ENSAMEP00000001288	Isopentenyl-diphosphate delta isomerase 1.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.	0.554
IDI1	SREBF2	ENSAMEP00000002011	ENSAMEP00000016386	Isopentenyl-diphosphate delta isomerase 1.	Sterol regulatory element binding transcription factor 2.	0.417