STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1500 aa)    
Predicted Functional Partners:
PRKACA
Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.
   
 0.956
PRKACB
Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.
   
 0.956
TJP1
Tight junction protein 1; Belongs to the MAGUK family.
     
 0.918
PRKAA1
Non-specific serine/threonine protein kinase.
   
 0.915
PRKAB2
Protein kinase AMP-activated non-catalytic subunit beta 2.
   
 0.913
PRKAA2
Non-specific serine/threonine protein kinase.
   
 0.913
PRKAB1
Protein kinase AMP-activated non-catalytic subunit beta 1.
   
 0.909
PRKAG3
Protein kinase AMP-activated non-catalytic subunit gamma 3.
   
  0.903
PRKAG1
Protein kinase AMP-activated non-catalytic subunit gamma 1.
   
  0.903
PRKAG2
Protein kinase AMP-activated non-catalytic subunit gamma 2.
   
  0.903
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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