| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CFTR | PRKAA1 | ENSAMEP00000001295 | ENSAMEP00000016287 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. | Non-specific serine/threonine protein kinase. | 0.915 |
| CFTR | PRKAA2 | ENSAMEP00000001295 | ENSAMEP00000018231 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. | Non-specific serine/threonine protein kinase. | 0.913 |
| CFTR | PRKAB1 | ENSAMEP00000001295 | ENSAMEP00000016939 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. | Protein kinase AMP-activated non-catalytic subunit beta 1. | 0.909 |
| CFTR | PRKAB2 | ENSAMEP00000001295 | ENSAMEP00000017991 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. | Protein kinase AMP-activated non-catalytic subunit beta 2. | 0.913 |
| CFTR | PRKACA | ENSAMEP00000001295 | ENSAMEP00000013901 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. | Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. | 0.956 |
| CFTR | PRKACB | ENSAMEP00000001295 | ENSAMEP00000014254 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.956 |
| CFTR | PRKAG1 | ENSAMEP00000001295 | ENSAMEP00000007369 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. | Protein kinase AMP-activated non-catalytic subunit gamma 1. | 0.903 |
| CFTR | PRKAG2 | ENSAMEP00000001295 | ENSAMEP00000014146 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. | Protein kinase AMP-activated non-catalytic subunit gamma 2. | 0.903 |
| CFTR | PRKAG3 | ENSAMEP00000001295 | ENSAMEP00000002839 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. | Protein kinase AMP-activated non-catalytic subunit gamma 3. | 0.903 |
| CFTR | TJP1 | ENSAMEP00000001295 | ENSAMEP00000003346 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. | Tight junction protein 1; Belongs to the MAGUK family. | 0.918 |
| PRKAA1 | CFTR | ENSAMEP00000016287 | ENSAMEP00000001295 | Non-specific serine/threonine protein kinase. | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. | 0.915 |
| PRKAA1 | PRKAA2 | ENSAMEP00000016287 | ENSAMEP00000018231 | Non-specific serine/threonine protein kinase. | Non-specific serine/threonine protein kinase. | 0.962 |
| PRKAA1 | PRKAB1 | ENSAMEP00000016287 | ENSAMEP00000016939 | Non-specific serine/threonine protein kinase. | Protein kinase AMP-activated non-catalytic subunit beta 1. | 0.999 |
| PRKAA1 | PRKAB2 | ENSAMEP00000016287 | ENSAMEP00000017991 | Non-specific serine/threonine protein kinase. | Protein kinase AMP-activated non-catalytic subunit beta 2. | 0.999 |
| PRKAA1 | PRKACA | ENSAMEP00000016287 | ENSAMEP00000013901 | Non-specific serine/threonine protein kinase. | Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. | 0.922 |
| PRKAA1 | PRKACB | ENSAMEP00000016287 | ENSAMEP00000014254 | Non-specific serine/threonine protein kinase. | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.923 |
| PRKAA1 | PRKAG1 | ENSAMEP00000016287 | ENSAMEP00000007369 | Non-specific serine/threonine protein kinase. | Protein kinase AMP-activated non-catalytic subunit gamma 1. | 0.999 |
| PRKAA1 | PRKAG2 | ENSAMEP00000016287 | ENSAMEP00000014146 | Non-specific serine/threonine protein kinase. | Protein kinase AMP-activated non-catalytic subunit gamma 2. | 0.990 |
| PRKAA1 | PRKAG3 | ENSAMEP00000016287 | ENSAMEP00000002839 | Non-specific serine/threonine protein kinase. | Protein kinase AMP-activated non-catalytic subunit gamma 3. | 0.987 |
| PRKAA2 | CFTR | ENSAMEP00000018231 | ENSAMEP00000001295 | Non-specific serine/threonine protein kinase. | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. | 0.913 |