PAXIP1 protein (Ailuropoda melanoleuca) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

PAXIP1

PAX interacting protein 1. (1249 aa)

Predicted Functional Partners:

RIF1

0.932

TP53BP1

0.896

PAGR1

0.863

SLF1

0.848

ATM

0.845

SMC6

0.843

RBBP5

0.830

NBN

0.805

NCOA6

0.786

KDM6A

0.779

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	NBN	ENSAMEP00000017701	ENSAMEP00000015863	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.980
ATM	PAXIP1	ENSAMEP00000017701	ENSAMEP00000001321	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	PAX interacting protein 1.	0.845
ATM	RIF1	ENSAMEP00000017701	ENSAMEP00000008937	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Replication timing regulatory factor 1.	0.817
ATM	SLF1	ENSAMEP00000017701	ENSAMEP00000008321	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SMC5-SMC6 complex localization factor 1.	0.850
ATM	TP53BP1	ENSAMEP00000017701	ENSAMEP00000016223	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tumor protein p53 binding protein 1.	0.963
KDM6A	NCOA6	ENSAMEP00000006146	ENSAMEP00000009695	Lysine demethylase 6A.	Nuclear receptor coactivator 6.	0.838
KDM6A	PAGR1	ENSAMEP00000006146	ENSAMEP00000015666	Lysine demethylase 6A.	PAXIP1 associated glutamate rich protein 1.	0.791
KDM6A	PAXIP1	ENSAMEP00000006146	ENSAMEP00000001321	Lysine demethylase 6A.	PAX interacting protein 1.	0.779
KDM6A	RBBP5	ENSAMEP00000006146	ENSAMEP00000001417	Lysine demethylase 6A.	RB binding protein 5, histone lysine methyltransferase complex subunit.	0.930
NBN	ATM	ENSAMEP00000015863	ENSAMEP00000017701	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.980
NBN	PAXIP1	ENSAMEP00000015863	ENSAMEP00000001321	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	PAX interacting protein 1.	0.805
NBN	RIF1	ENSAMEP00000015863	ENSAMEP00000008937	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	Replication timing regulatory factor 1.	0.499
NBN	SLF1	ENSAMEP00000015863	ENSAMEP00000008321	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	SMC5-SMC6 complex localization factor 1.	0.870
NBN	TP53BP1	ENSAMEP00000015863	ENSAMEP00000016223	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	Tumor protein p53 binding protein 1.	0.751
NCOA6	KDM6A	ENSAMEP00000009695	ENSAMEP00000006146	Nuclear receptor coactivator 6.	Lysine demethylase 6A.	0.838
NCOA6	PAGR1	ENSAMEP00000009695	ENSAMEP00000015666	Nuclear receptor coactivator 6.	PAXIP1 associated glutamate rich protein 1.	0.798
NCOA6	PAXIP1	ENSAMEP00000009695	ENSAMEP00000001321	Nuclear receptor coactivator 6.	PAX interacting protein 1.	0.786
NCOA6	RBBP5	ENSAMEP00000009695	ENSAMEP00000001417	Nuclear receptor coactivator 6.	RB binding protein 5, histone lysine methyltransferase complex subunit.	0.963
PAGR1	KDM6A	ENSAMEP00000015666	ENSAMEP00000006146	PAXIP1 associated glutamate rich protein 1.	Lysine demethylase 6A.	0.791
PAGR1	NCOA6	ENSAMEP00000015666	ENSAMEP00000009695	PAXIP1 associated glutamate rich protein 1.	Nuclear receptor coactivator 6.	0.798