RFWD3 protein (Ailuropoda melanoleuca) - STRING interaction network

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RFWD3

E3 ubiquitin-protein ligase RFWD3; E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage. Plays a key role in RPA-mediated DNA damage signaling and repair. Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination. Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA [...] (790 aa)

Predicted Functional Partners:

RPA3

0.961

RPA1

0.950

PRIMPOL

0.935

SMARCAL1

0.841

G1L0X7_AILME

0.778

WRN

0.778

RPA2

0.777

TIMELESS

0.683

WDR59

0.634

B2M

0.609

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	G1L0X7_AILME	ENSAMEP00000020170	ENSAMEP00000000529	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Uncharacterized protein.	0.813
B2M	PRIMPOL	ENSAMEP00000020170	ENSAMEP00000008927	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Primase and DNA directed polymerase.	0.625
B2M	RFWD3	ENSAMEP00000020170	ENSAMEP00000001391	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	E3 ubiquitin-protein ligase RFWD3; E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage. Plays a key role in RPA-mediated DNA damage signaling and repair. Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination. Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA [...]	0.609
B2M	RPA1	ENSAMEP00000020170	ENSAMEP00000008180	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.967
B2M	RPA3	ENSAMEP00000020170	ENSAMEP00000017314	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Replication protein A3.	0.966
B2M	SMARCAL1	ENSAMEP00000020170	ENSAMEP00000003591	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.735
B2M	TIMELESS	ENSAMEP00000020170	ENSAMEP00000004203	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Timeless circadian regulator.	0.631
B2M	WRN	ENSAMEP00000020170	ENSAMEP00000001717	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	3'-5' exonuclease domain-containing protein.	0.813
G1L0X7_AILME	B2M	ENSAMEP00000000529	ENSAMEP00000020170	Uncharacterized protein.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.813
G1L0X7_AILME	PRIMPOL	ENSAMEP00000000529	ENSAMEP00000008927	Uncharacterized protein.	Primase and DNA directed polymerase.	0.423
G1L0X7_AILME	RFWD3	ENSAMEP00000000529	ENSAMEP00000001391	Uncharacterized protein.	E3 ubiquitin-protein ligase RFWD3; E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage. Plays a key role in RPA-mediated DNA damage signaling and repair. Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination. Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA [...]	0.778
G1L0X7_AILME	RPA1	ENSAMEP00000000529	ENSAMEP00000008180	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.930
G1L0X7_AILME	RPA2	ENSAMEP00000000529	ENSAMEP00000011708	Uncharacterized protein.	Replication protein A2.	0.813
G1L0X7_AILME	RPA3	ENSAMEP00000000529	ENSAMEP00000017314	Uncharacterized protein.	Replication protein A3.	0.932
G1L0X7_AILME	SMARCAL1	ENSAMEP00000000529	ENSAMEP00000003591	Uncharacterized protein.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.664
G1L0X7_AILME	TIMELESS	ENSAMEP00000000529	ENSAMEP00000004203	Uncharacterized protein.	Timeless circadian regulator.	0.879
G1L0X7_AILME	WRN	ENSAMEP00000000529	ENSAMEP00000001717	Uncharacterized protein.	3'-5' exonuclease domain-containing protein.	0.978
PRIMPOL	B2M	ENSAMEP00000008927	ENSAMEP00000020170	Primase and DNA directed polymerase.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.625
PRIMPOL	G1L0X7_AILME	ENSAMEP00000008927	ENSAMEP00000000529	Primase and DNA directed polymerase.	Uncharacterized protein.	0.423
PRIMPOL	RFWD3	ENSAMEP00000008927	ENSAMEP00000001391	Primase and DNA directed polymerase.	E3 ubiquitin-protein ligase RFWD3; E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage. Plays a key role in RPA-mediated DNA damage signaling and repair. Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination. Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA [...]	0.935

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