Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SPIRE2Spire type actin nucleation factor 2. (637 aa)    
Predicted Functional Partners:
GRAP2
GRB2 related adaptor protein 2.
   
 0.816
FMN1
Formin 1.
    
 0.775
G1M644_AILME
FH2 domain-containing protein.
    
 0.775
GRB2
Growth factor receptor bound protein 2.
    
 0.765
LAT
Linker for activation of T cells.
    
 0.729
MYO5B
Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 0.668
PFDN4
Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family.
      
 0.633
MYO5C
Myosin VC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 0.632
MYO5A
Myosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 0.632
PLCG1
Phosphoinositide phospholipase C.
   
 0.609
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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