MET protein (Ailuropoda melanoleuca) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MET

MET proto-oncogene, receptor tyrosine kinase. (1400 aa)

Predicted Functional Partners:

CBL

0.999

HGF

0.999

GAB1

0.990

PLXNB1

0.986

PLXNB3

0.986

GRB2

0.985

ERBB3

0.976

KRAS

0.965

SRC

0.963

PIK3CA

0.961

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBL	ERBB3	ENSAMEP00000008385	ENSAMEP00000003549	Cbl proto-oncogene.	Erb-b2 receptor tyrosine kinase 3.	0.768
CBL	GRB2	ENSAMEP00000008385	ENSAMEP00000009814	Cbl proto-oncogene.	Growth factor receptor bound protein 2.	0.998
CBL	HGF	ENSAMEP00000008385	ENSAMEP00000017509	Cbl proto-oncogene.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.520
CBL	MET	ENSAMEP00000008385	ENSAMEP00000001400	Cbl proto-oncogene.	MET proto-oncogene, receptor tyrosine kinase.	0.999
CBL	PIK3CA	ENSAMEP00000008385	ENSAMEP00000011350	Cbl proto-oncogene.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.856
CBL	SRC	ENSAMEP00000008385	ENSAMEP00000012975	Cbl proto-oncogene.	Tyrosine-protein kinase.	0.871
ERBB3	CBL	ENSAMEP00000003549	ENSAMEP00000008385	Erb-b2 receptor tyrosine kinase 3.	Cbl proto-oncogene.	0.768
ERBB3	GAB1	ENSAMEP00000003549	ENSAMEP00000010179	Erb-b2 receptor tyrosine kinase 3.	GRB2 associated binding protein 1.	0.968
ERBB3	GRB2	ENSAMEP00000003549	ENSAMEP00000009814	Erb-b2 receptor tyrosine kinase 3.	Growth factor receptor bound protein 2.	0.988
ERBB3	HGF	ENSAMEP00000003549	ENSAMEP00000017509	Erb-b2 receptor tyrosine kinase 3.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.921
ERBB3	KRAS	ENSAMEP00000003549	ENSAMEP00000007949	Erb-b2 receptor tyrosine kinase 3.	KRAS proto-oncogene, GTPase.	0.697
ERBB3	MET	ENSAMEP00000003549	ENSAMEP00000001400	Erb-b2 receptor tyrosine kinase 3.	MET proto-oncogene, receptor tyrosine kinase.	0.976
ERBB3	PIK3CA	ENSAMEP00000003549	ENSAMEP00000011350	Erb-b2 receptor tyrosine kinase 3.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.976
ERBB3	PLXNB1	ENSAMEP00000003549	ENSAMEP00000001394	Erb-b2 receptor tyrosine kinase 3.	Plexin B1.	0.464
ERBB3	PLXNB3	ENSAMEP00000003549	ENSAMEP00000019522	Erb-b2 receptor tyrosine kinase 3.	Plexin B3.	0.464
ERBB3	SRC	ENSAMEP00000003549	ENSAMEP00000012975	Erb-b2 receptor tyrosine kinase 3.	Tyrosine-protein kinase.	0.963
GAB1	ERBB3	ENSAMEP00000010179	ENSAMEP00000003549	GRB2 associated binding protein 1.	Erb-b2 receptor tyrosine kinase 3.	0.968
GAB1	GRB2	ENSAMEP00000010179	ENSAMEP00000009814	GRB2 associated binding protein 1.	Growth factor receptor bound protein 2.	0.999
GAB1	HGF	ENSAMEP00000010179	ENSAMEP00000017509	GRB2 associated binding protein 1.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.637
GAB1	MET	ENSAMEP00000010179	ENSAMEP00000001400	GRB2 associated binding protein 1.	MET proto-oncogene, receptor tyrosine kinase.	0.990