Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SHC4SHC adaptor protein 4. (630 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor bound protein 2.
    
 0.961
ERBB3
Erb-b2 receptor tyrosine kinase 3.
    
 0.951
ERBB4
Receptor protein-tyrosine kinase.
    
 0.951
ERBB2
Receptor protein-tyrosine kinase.
    
 0.951
GAB1
GRB2 associated binding protein 1.
    
 0.938
INSR
Tyrosine-protein kinase receptor.
    
 0.934
MET
MET proto-oncogene, receptor tyrosine kinase.
   
 0.933
FGFR3
Fibroblast growth factor receptor.
   
 0.925
SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2.
    
 0.921
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
    
 0.921
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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