UCN protein (Ailuropoda melanoleuca) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

UCN

Urocortin. (123 aa)

Predicted Functional Partners:

CRHR2

0.994

G1M7R8_AILME

0.994

UCN2

0.976

UCN3

0.973

CRHBP

0.839

TAS1R3

0.807

ATP6

0.770

TRMU

0.737

CYTB

0.680

ATP8

0.668

Your Current Organism:

Ailuropoda melanoleuca

NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP6	ATP8	ENSAMEP00000021358	ENSAMEP00000021357	ATP synthase subunit a.	ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...]	0.999
ATP6	CYTB	ENSAMEP00000021358	ENSAMEP00000021365	ATP synthase subunit a.	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	0.999
ATP6	UCN	ENSAMEP00000021358	ENSAMEP00000001698	ATP synthase subunit a.	Urocortin.	0.770
ATP8	ATP6	ENSAMEP00000021357	ENSAMEP00000021358	ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...]	ATP synthase subunit a.	0.999
ATP8	CYTB	ENSAMEP00000021357	ENSAMEP00000021365	ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...]	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	0.998
ATP8	UCN	ENSAMEP00000021357	ENSAMEP00000001698	ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...]	Urocortin.	0.668
CRHBP	CRHR2	ENSAMEP00000001924	ENSAMEP00000007077	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	0.680
CRHBP	G1M7R8_AILME	ENSAMEP00000001924	ENSAMEP00000015388	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.721
CRHBP	UCN	ENSAMEP00000001924	ENSAMEP00000001698	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	Urocortin.	0.839
CRHR2	CRHBP	ENSAMEP00000007077	ENSAMEP00000001924	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	0.680
CRHR2	G1M7R8_AILME	ENSAMEP00000007077	ENSAMEP00000015388	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.904
CRHR2	UCN	ENSAMEP00000007077	ENSAMEP00000001698	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	Urocortin.	0.994
CRHR2	UCN2	ENSAMEP00000007077	ENSAMEP00000019944	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	Urocortin 2.	0.984
CRHR2	UCN3	ENSAMEP00000007077	ENSAMEP00000020473	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	Urocortin 3.	0.970
CYTB	ATP6	ENSAMEP00000021365	ENSAMEP00000021358	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	ATP synthase subunit a.	0.999
CYTB	ATP8	ENSAMEP00000021365	ENSAMEP00000021357	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...]	0.998
CYTB	UCN	ENSAMEP00000021365	ENSAMEP00000001698	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	Urocortin.	0.680
G1M7R8_AILME	CRHBP	ENSAMEP00000015388	ENSAMEP00000001924	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	0.721
G1M7R8_AILME	CRHR2	ENSAMEP00000015388	ENSAMEP00000007077	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	0.904
G1M7R8_AILME	UCN	ENSAMEP00000015388	ENSAMEP00000001698	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Urocortin.	0.994