STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MPLMPL proto-oncogene, thrombopoietin receptor. (624 aa)    
Predicted Functional Partners:
THPO
Thrombopoietin.
    
 0.985
JAK2
Tyrosine-protein kinase.
    
 0.828
EPO
Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.
     
 0.755
JAK3
Tyrosine-protein kinase.
    
 0.752
LOC100473242
Uncharacterized protein.
     
 0.752
CSF2
Colony stimulating factor 2.
  
  
 0.740
TYK2
Tyrosine-protein kinase.
    
 0.737
JAK1
Tyrosine-protein kinase.
    
 0.726
CSF3
Colony stimulating factor 3.
     
 0.714
IL13
Interleukin 13.
  
  
  0.709
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.