Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
G1L4H4_AILMEMAGE domain-containing protein. (783 aa)    
Predicted Functional Partners:
NSMCE4A
Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
   
 0.868
NSMCE1
NSE1 homolog, SMC5-SMC6 complex component.
   
 0.864
SMC5
SMC_N domain-containing protein.
   
 0.776
SMC6
Uncharacterized protein.
   
 0.758
NSMCE2
NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.
   
 0.756
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.755
EID1
Uncharacterized protein.
   
 
 0.702
E2F1
E2F transcription factor 1.
    
 
 0.601
RIC8B
RIC8 guanine nucleotide exchange factor B.
    
   0.566
NPAS4
Neuronal PAS domain protein 4.
    
 0.520
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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