STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NUDT16L1Nudix hydrolase 16 like 1. (210 aa)    
Predicted Functional Partners:
SDC4
Syndecan 4.
     
 0.915
TP53BP1
Tumor protein p53 binding protein 1.
    
 
 0.813
CDC25A
Cell division cycle 25A.
      
 0.718
SLC25A39
Solute carrier family 25 member 39; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.625
RNF146
E3 ubiquitin-protein ligase RNF146; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CA [...]
      
 0.573
EME2
Essential meiotic structure-specific endonuclease subunit 2.
   
  
 0.538
TOMM5
Translocase of outer mitochondrial membrane 5.
      
 0.529
AP2S1
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
      
 0.529
MTFP1
Mitochondrial fission process 1.
      
 0.528
RPLP2
Ribosomal protein large P2; Belongs to the eukaryotic ribosomal protein P1/P2 family.
   
  
 0.487
Your Current Organism:
Ailuropoda melanoleuca
NCBI taxonomy Id: 9646
Other names: A. melanoleuca, giant panda
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.